Need an excuse for an extended coffee break? Or, in European countries, another smoke break?
Search for a command in AutoCAD 2009's Customize User Interface dialog box. Fer instance, to find the "About" command (alphabetically, the very first one), takes 13 seconds. It turns out every command takes 13 seconds on my computer running the shipping version of AutoCAD 2009.
The file being searched is named acad.cui and, optionally, other .cui files. They are in XML (ASCII) format and 2.7MB or less in size. It surprises me that text searches could take so long in this day of dual-core 2+GHz machines with multi-gigabytes of RAM.